Technology Review Wednesday, July 30, 2008
A tiny microscope that employs the same kind of chip used in digital cameras can produce high-resolution images of cells without the expensive, space-hogging lenses that have been part of microscope design for centuries. Researchers at Caltech, who developed the revolutionary imaging system, say that the devices could be mass-produced at a cost of $10 each and incorporated into large arrays, enabling high-throughput imaging in biology labs. The device could also broaden access to imaging technology: incorporated into PDA-size devices, for example, the microscopes could enable rural doctors to carry sophisticated imaging systems in their pockets.
The Caltech device uses a system of tiny fluid channels called microfluidics to direct cells and even microscopic animals over a light-sensing chip. The chip, an off-the-shelf sensor identical to those found in digital cameras, is covered with a thin layer of metal that blocks out most of the pixels. A few hundred tiny apertures punched in the metal along the fluid channel let light in. As the sample flows through the microscope, each aperture captures an image.
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The Caltech device uses a system of tiny fluid channels called microfluidics to direct cells and even microscopic animals over a light-sensing chip. The chip, an off-the-shelf sensor identical to those found in digital cameras, is covered with a thin layer of metal that blocks out most of the pixels. A few hundred tiny apertures punched in the metal along the fluid channel let light in. As the sample flows through the microscope, each aperture captures an image.
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